Screening of Dodonaea Viscosa Linn (Sapindaceae) for Antibacterial and Cytotoxic Activities


  • Oumar Al-Moubrak Adoum Department of Pure and industrial Chemistry, Bayero University, Kano P.M.B. 3011, Kano, Nigeria
  • Abubakar Sani Department of Pure and industrial Chemistry, Faculty of Natural and Applied Sciences, Umaru Musa Yar’adua University, Dutsin-ma Road, P.M.B,2218, Katsina, Nigeria


Antibacterial activity, Cytotoxicity, Dodonaea viscosa Linn


The crude ethanol extract of Dodonaea viscosa Linn (Sapindaceae) was partitioned into chloroform, aqueous, ethyl acetate, methanol and n-hexane soluble fractions. The extract and five fractions were tested against the larvae of Artemia saline [Brine Shrimp Lethality Tes (BST)]. The aqueous and methanol extracts were found to exhibited remarkable toxicity on brine
shrimp larva at LC50 value of 0.1326 and 62.5 μg/ml, while no activity recorded in the ethanol, chloroform, ethyl acetate, and n-hexane fractions LC50 value >1000 μg/ml. The crude ethanol extract and five solvent fractions were tested for antimicrobial activity using agar diffusion method and the results revealed the zone of inhibition 15.0 mm at 10,000μg/ml was exhibited by
the aqueous soluble fraction of the leaves of Dodonaea viscosa against S. typhi. Meanwhile, methanol and ethanol fractions of Dodonaea viscosa exhibited zone of growth inhibition 15mm and 30mm against S. aureus, at 10,000μg/ml.